Luận án Nghiên cứu nồng độ lipoprotein-Associated phospholipase A2 huyết thanh ở bệnh nhân nhồi máu não giai đoạn cấp

Table 3.12 shows that there is a significant correlation

between serum Lp-PLA2 concentration and cerebral infarction

volume. Patients in group with increased Lp-PLA2 have larger

ischemic area in comparison with patients in group with normal LpPLA2 (11.00 ml vs 1.40 ml; p < 0.05).

There is a strong positive correlation between Lp-PLA2

concentration with ischemic volume ( r = 0.58, p < 0.05).

In addition, we also found that the disorders of consciousness

evaluated by Glasgow scale and the extent of neurological impairment

assessed by NIHSS are significant associated with ischemic volume.

Kara H et al (2014) reported a significant difference of LpPLA2 activity between case group and control group (113 ± 86 nmol

/ min / ml ± 50 nmol vs 103 / min / ml; p <0.001) , as well as hs-CRP

of case group (7 ± 6 mg/dl) and control group (1 ± 1 mg/dl) with p

<0.001. There is a significant association between Lp-PLA2

concentration, hs-CRP and the clinical status, ischemic volume in

patients with acute cerebral infarction.

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